• TandAb® Antibodies

    Affimed`s unique and fully patented TandAb® antibody platform is generating superior antibody therapeutics.

  • AFM13

    Affimed´s lead program AFM13 enjoys early recognition and protection due to its designation as an Orphan Drug.

  • RECRUIT-TandAb®

    RECRUIT-TandAbs® specifically kill various tumor types by recruiting NK- or T-cells.

  • Business Strategy

    Affimed is building a mature pipeline of unique therapeutic antibodies for partnership following preclinical or clinical proof of concept studies.

About Affimed

Affimed is a therapeutic antibody company developing unique antibody formats for the treatment of cancer, such as hematological and solid tumors as well as for inflammatory diseases based on its proprietary TandAb® technology platform.

TandAb® Technology

TandAbs® are tetravalent bispecific antibody formats that have two binding sites for each antigen. They bind to target molecules on the surface of, for example,tumor cells and can activate immune effector cells like cytotoxic T-cells or natural killer (NK) cells.

Tandab® RECRUIT

Product Pipeline

Compound Target Indication Discovery Preclinical Phase I Phase II
AFM13 CD30xCD16 Hodgkin’s Lymphoma 100% completed 100% completed 100% completed end 2011 100% completed end 2012
AFM11 CD19xCD3 Non-Hodgkin’s Lymphoma 100% completed 50% completed 100% end 2010 100% completed end 2012 50% end 2012
AFM12 CD19xCD16 Non-Hodgkin’s Lymphoma 100% completed 50% completed 100% completed end 2012 - -

All our TandAb® Products

AFM13

The TandAb® antibody, AFM13, is a bispecific, tetravalent human antibody specifically designed to treat Hodgkin’s lymphoma. AFM13 is a RECRUIT-TandAb® targeting CD30 on the tumor target cells (Reed-Sternberg cells) and CD16A on NK-cells as immune effector cells. Preclinical data indicate a specific and very effective engagement of NK-cells inducing fast and strong ADCC in combination with good safety and tolerability.

More about AFM13